Wong K, Hughes C A, Plitt S, Foisy M, MacDonald J, Johnson M, Singh A E
Alberta Health Services, Capital Health, Calgary, Canada.
Int J STD AIDS. 2010 Sep;21(9):617-21. doi: 10.1258/ijsa.2008.008482.
Provincial guidelines for HIV non-occupational postexposure prophylaxis (NPEP) were implemented on January 2005 in Alberta, Canada. Human immunodeficiency virus (HIV) NPEP was provided free of charge following approval by a medical officer of health. Between 1 January 2005 and 30 June 2007, 174 individuals were prescribed NPEP; 135 (78%) were women with a median age of 24 years. Sexual assaults accounted for 68% of exposures. NPEP was completed in 49% of cases. Individuals who completed NPEP were less likely to have been exposed by sexual assault (P = 0.04) and more likely to have received HIV follow-up testing (P = 0.03).Individuals who received at least one HIV follow-up test were older (P = 0.03) and more likely to have been exposed percutaneously (P = 0.003). Those who received no follow-up testing were less likely to have filled an NPEP prescription (P = 0.0001). New strategies are required to improve follow-up of individuals receiving NPEP, especially younger persons or sexual assault survivors.
加拿大艾伯塔省于2005年1月实施了省级非职业性HIV暴露后预防（NPEP）指南。经卫生官员批准后，可免费提供HIV暴露后预防用药。在2005年1月1日至2007年6月30日期间，有174人接受了NPEP治疗；其中135人（78%）为女性，年龄中位数为24岁。性侵犯占暴露情况的68%。49%的病例完成了NPEP治疗。完成NPEP治疗的个体因性侵犯而暴露的可能性较小（P = 0.04），接受HIV后续检测的可能性较大（P = 0.03）。接受至少一次HIV后续检测的个体年龄较大（P = 0.03），经皮暴露的可能性也较大（P = 0.003）。未接受后续检测的个体开具NPEP处方的可能性较小（P = 0.0001）。需要采取新策略来改善接受NPEP治疗个体的后续跟踪，尤其是年轻人或性侵犯幸存者。
