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[胰岛素依赖型糖尿病患者胰岛细胞培养物门静脉内同种异体移植的结果]

[The results of the intraportal allotransplantation of pancreatic islet cell cultures in patients with insulin-dependent diabetes mellitus].

作者信息

Boĭko N I, Pavlovskiĭ M P

出版信息

Probl Endokrinol (Mosk). 1990 Jan-Feb;36(1):11-3.

PMID:2109863
Abstract

The paper is concerned with the results of the treatment of 11 patients with insulin-dependent diabetes mellitus with surgical pathology by a method of intraportal allotransplantation of pancreatic islet cell (PIC) cultures and with similar surgical pathology without PIC transplantation. Carbohydrate metabolism and the level of plasma hormones were investigated. It has been shown that intraportal administration of PIC suspension into the liver can result in an earlier and more considerable decrease in a dose of exogenous insulin that is very important in the postoperative period. This method permitted double reduction of diabetic patients' stay in hospital.

摘要

本文关注的是采用胰岛细胞(PIC)培养物门静脉同种异体移植方法对11例胰岛素依赖型糖尿病患者进行手术病理治疗的结果,以及未进行PIC移植的类似手术病理情况。研究了碳水化合物代谢和血浆激素水平。结果表明,将PIC悬浮液门静脉内注入肝脏可使外源性胰岛素剂量更早且更显著地降低,这在术后时期非常重要。该方法使糖尿病患者的住院时间缩短了一半。

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