Goncharova Nadezhda D, Marenin Victor Y, Oganyan Tamara E
Laboratory of Endocrinology, Research Institute of Medical Primatology of the Russian Academy of Medical Sciences, Sochi, Adler, Veseloye 1, 354376, Russian Federation.
Aging (Albany NY). 2010 Nov;2(11):854-66. doi: 10.18632/aging.100227.
We have investigated aging of the hypothalamic-pituitary-adrenal (HPA) axis in female rhesus monkeys that differ in adaptive behavior. Plasma cortisol (F) and dehydroepiandrosterone sulfate (DHEA-S) concentrations under basal conditions and under acute psycho-emotional stress were evaluated in blood plasma of young (6-8 years) and old (20-27 years) female rhesus monkeys with various types of adaptive behavior (aggressive, depression-like, and average). We have found that the age-related changes in the HPA axis of monkeys with depression-like behavior were accompanied by the maximal absolute and relative hypercortisolemia under both basal conditions and stress. Moreover, young aggressive monkeys, in comparison with young monkeys of other behavior groups, demonstrated the highest plasma levels of DHEA-S and the lowest molar ratios between F and DHEA-S. Thus, age-related dysfunctions of the HPA axis are associated with adaptive behavior of animals.
我们研究了具有不同适应行为的雌性恒河猴下丘脑 - 垂体 - 肾上腺（HPA）轴的老化情况。评估了年轻（6 - 8岁）和年老（20 - 27岁）、具有不同适应行为类型（攻击性、抑郁样和平均水平）的雌性恒河猴在基础条件下以及急性心理 - 情绪应激下血浆皮质醇（F）和硫酸脱氢表雄酮（DHEA - S）的浓度。我们发现，具有抑郁样行为的猴子的HPA轴与年龄相关的变化伴随着基础条件和应激下最大的绝对和相对高皮质醇血症。此外，与其他行为组的年轻猴子相比，年轻的攻击性猴子表现出最高的血浆DHEA - S水平和最低的F与DHEA - S摩尔比。因此，HPA轴与年龄相关的功能障碍与动物的适应行为有关。
