Zurabashvili D Z, Giorgobiani I B, Arveladze M A, Gamkrelidze I A, Kavsadze E N
Georgian Med News. 2010 Oct(187):65-8.
The aim of this work was to evaluate the hypothesis that the second-generation antidepressant, might play a role in controlling the activity of noradrenalergic neurotransmitters. The paper details the pharmacological profile of antidepressant drug Fluoxetive with high affinity for 5-HT receptor, and explains how the antidepressant activity chances noradrenalin reuptake inhibitor-medications. Brain cortexes of 20 rabbits were analyzed by high-performance liquid chromatography. The conducted quantitative and qualitative analyzes show that antidepressant activity of Fluoxetine could be mediated by the synergistic effects on the serotoninergic and noradrenergic receptor pathways. Major depressive disorders are heterogeneous monoamine condition. Our studies have demonstrated fluoxetine efficacy and safety for treatment of major depressive disorders.
这项工作的目的是评估第二代抗抑郁药可能在控制去甲肾上腺素能神经递质活性中发挥作用这一假设。该论文详细介绍了对5-羟色胺受体具有高亲和力的抗抑郁药氟西汀的药理学特性，并解释了抗抑郁活性如何改变去甲肾上腺素再摄取抑制剂药物的作用。通过高效液相色谱法分析了20只兔子的大脑皮层。进行的定量和定性分析表明，氟西汀的抗抑郁活性可能是由对血清素能和去甲肾上腺素能受体途径的协同作用介导的。重度抑郁症是异质性单胺疾病。我们的研究已经证明氟西汀治疗重度抑郁症的有效性和安全性。
