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肾包膜平滑肌瘤:病例报告

Renal capsule leiomyoma: case report.

作者信息

Ramírez Fernández Juan Carlos, Mohamed Zaki Mohamed, Casado Varela Javier, Salinas Casado Jesús, Wert Ortega Ricardo, García-Cabezas Miguel Angel

机构信息

Hospital Ruber Internacional, Madrid, Spain.

出版信息

Arch Esp Urol. 2010 Nov;63(9):808-11.

Abstract

OBJECTIVE

We present a case of leiomyoma of the renal capsule in a 49 year-old woman that was detected incidentally during an abdominal study for gastroesophageal reflux. We discuss the clinical, radiological and pathological diagnosis of renal leiomyoma as well as its treatment alternatives.

METHODS

Ultrasonography, CT and MRI were performed. A conventional pathological analysis including immunohistochemistry was performed after radical nephrectomy.

RESULTS

Ultrasonography detected a solid hypoechoic mass poorly vascularized in the upper pole of the right kidney. CT and MRI detected a well-delimited mass showing soft tissue density without extension to the neighbor structures and without lymphadenopathies. Radical nephrectomy was performed. Microscopically, the mass was made of a low-grade fusocellular proliferation with cells staining with antibodies against smooth muscle markers. The mass was in continuity with the renal capsule and compressed slightly the renal parenchyma without damaging it.

CONCLUSIONS

Renal leiomyomas are unfrequent benign tumors that should be suspected in young and middle aged women showing asymptomatic, well delimited and hypoechoic renal tumors with soft tissue density in CT scans. When vascular structures are not involved by the tumor, a conservative surgical intervention could be the first therapeutic option. Microscopically, renal leiomyomas are low-grade fusocellular tumors showing a smooth muscle immunohistochemical profile.

摘要

目的

我们报告一例49岁女性肾包膜平滑肌瘤病例,该病例在因胃食管反流进行腹部检查时偶然发现。我们讨论肾平滑肌瘤的临床、放射学和病理学诊断及其治疗选择。

方法

进行了超声检查、CT和MRI检查。根治性肾切除术后进行了包括免疫组织化学在内的常规病理分析。

结果

超声检查在右肾上极发现一个实性低回声肿块,血供不良。CT和MRI发现一个边界清晰的肿块,显示软组织密度,未延伸至邻近结构,无淋巴结肿大。进行了根治性肾切除术。显微镜下,肿块由低度梭形细胞增生构成,细胞对平滑肌标志物抗体呈阳性染色。肿块与肾包膜相连,轻度压迫肾实质但未造成损伤。

结论

肾平滑肌瘤是罕见的良性肿瘤,对于中青年女性出现无症状、边界清晰且CT扫描显示软组织密度的低回声肾肿瘤应怀疑此病。当肿瘤未累及血管结构时,保守性手术干预可能是首选治疗方案。显微镜下,肾平滑肌瘤是低度梭形细胞肿瘤,显示平滑肌免疫组化特征。

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