Department of Physiology and Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Islets. 2009 Nov-Dec;1(3):169-76. doi: 10.4161/isl.1.3.9262.
It has long been believed that heavy metals possess many adverse health effects. Uncontrolled industrialization has released heavy metal pollution in the world. Heavy metal pollutants damage organ functions and disrupt physiological homeostasis. Diabetes mellitus is growing in prevalence worldwide. Several studies have indicated that the deficiency and efficiency of some essential trace metals may play a role in the islet function and development of diabetes mellitus. Some toxic metals have also been shown to be elevated in biological samples of diabetes mellitus patients. In the present work, we review the important roles of heavy metals in islet function and diabetes development in which the in vitro, in vivo or human evidences are associated with exposure to zinc, arsenic, cadmium, mercury and nickel. Through this work, we summarize the evidence which suggests that some heavy metals may play an important role in diabetes mellitus as environmental risk factors.
长期以来，人们一直认为重金属具有许多不良的健康影响。不受控制的工业化已经在世界范围内释放了重金属污染。重金属污染物会损害器官功能并破坏生理内稳态。糖尿病在全球范围内的患病率不断上升。有几项研究表明，一些必需微量元素的缺乏和效率可能在胰岛功能和糖尿病的发展中起作用。一些有毒金属也已被证明在糖尿病患者的生物样本中升高。在本工作中，我们综述了重金属在胰岛功能和糖尿病发展中的重要作用，其中体外、体内或人类证据与锌、砷、镉、汞和镍的暴露有关。通过这项工作，我们总结了一些重金属可能作为环境风险因素在糖尿病中起重要作用的证据。
