Hospital Carlos III, Madrid, Spain bDuke Clinical Research Institute, Durham, North Carolina, USA.
AIDS. 2011 Jan 14;25(2):269-71. doi: 10.1097/QAD.0b013e328341b84e.
The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.
白细胞介素-28B（IL28B）/干扰素-λ3（IFN-λ3）多态性在丙型肝炎病毒感染易感性和聚乙二醇干扰素-利巴韦林治疗反应中的关键作用，促使人们探索其在其他病毒上的类似作用。鉴于 IFN-λ 介导抗 HIV-1 活性，研究人员在 29 名有感染 HIV 风险的血清阴性个体和 68 名 HIV 阳性携带者（包括免疫缺陷快速进展和未快速进展的个体）中，检测了 IL28B 多态性的保护性作用。在研究 HIV 疾病进展和 HIV 保护时，均未发现 IL28B 多态性的保护性作用。
