University College Hospital, UK.
Curr Opin Urol. 2011 Jan;21(1):36-41. doi: 10.1097/MOU.0b013e3283411455.
Electrosurgical transurethral resection (TUR) of the prostate (TURP) has dominated symptomatic benign prostatic hyperplasia (s-BPH) surgical treatment for almost a century. We analysed recent TURP publications, with emphasis on durability, morbidity, new technology advantages, future generation training and malignant disease.
TURP has declined due to medical therapy, but transcends other surgical challengers by proven outcomes durability over a decade. Adopting the modified-Clavien system may aid future morbidity comparisons. Properly used bipolar technology reduces major bleeding and seemingly abolishes TUR syndrome, but requires further study in anticoagulated patients. Residents are disturbingly short of TURP exposure, consequently experiencing more complications. Solutions include switching to ablative laser prostatectomy (which may carry higher long-term retreatment rates), adoption of bipolar technology, or simulator development and implementation. Concurrently performed transurethral resection of bladder tumor-TURP seems oncologically acceptable (in selected cases); incidentally detected significant prostate cancer at TURP may have declined, whereas TURP for prostate cancer may indicate the need for earlier androgen deprivation.
TURP is still rightly the dominant, most widely performed, versatile and cost-effective surgical treatment for s-BPH, reducing morbidity further with technical and technological developments. A better evidence base is required for newer technologies through large well designed multicentre-multinational randomized controlled trials incorporating standardized morbidity and long-term outcomes reporting.
经尿道前列腺电切术(TURP)治疗症状性良性前列腺增生(s-BPH)已有近一个世纪的历史,主导着该疾病的手术治疗。我们分析了最近关于 TURP 的文献,重点关注其耐久性、发病率、新技术优势、新一代培训和恶性疾病。
由于药物治疗的发展,TURP 的应用有所减少,但通过超过十年的验证结果耐久性,它仍然优于其他手术治疗方法。采用改良的 Clavien 系统可能有助于未来对发病率的比较。适当使用双极技术可减少大出血,似乎可消除 TUR 综合征,但在抗凝患者中仍需进一步研究。住院医师 TURP 操作经验明显不足,因此会出现更多并发症。解决方案包括改用激光前列腺切除术(可能会带来更高的长期复发率)、采用双极技术或开发和实施模拟器。同期进行的经尿道膀胱肿瘤切除术(TURBT)-TURP 在肿瘤学上似乎是可以接受的(在特定情况下);在 TURP 中偶然发现的有意义的前列腺癌可能已经减少,而 TURP 治疗前列腺癌可能表明需要更早的雄激素剥夺治疗。
TURP 仍然是治疗 s-BPH 的主导性、最广泛应用、最具多功能性和成本效益的手术治疗方法,通过技术和技术的发展进一步降低发病率。需要通过大型、设计良好的多中心、多国随机对照试验,纳入标准化发病率和长期结果报告,为新技术提供更好的证据基础。