Abdel Mawla M M
Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo.
J Egypt Soc Parasitol. 1990 Jun;20(1):319-25.
Electron microscopy of skeletal muscle biopsy from a case of human sarcocystosis revealed a new cyst type of S. lindemanni. The sarcocyst appeared large having a thick cyst wall with evident septa extending into the cyst and, characteristically, broad branched cauliflower like protrusions extending into the pericystic zone. This cyst type appeared to be highly pathogenic. In addition to the complete myofibrillar lysis of the infected muscle-fibre, there were delamination of the neighbouring myofibres, disruption of the sarcomeric orientation with dearrangement and bending oft he Z bands and loss of the T and L myofibrillar pattern in the pericystic zone. Features of myositis such as the presence of abundant lysosomal structures, myofibrillar disarray and glycogen formations were detected. These cytopathogenic signs were obviously attributed to the structural criterion of the cyst wall. The findings not only invalidate the concept that pathological conditions associated with human sarcocytosis are accidental, but also stress the value of electron microscopy in inducing relevant typing of sarcocysts on basis of their morphologically expressed pathogenic properties.
对一例人体肉孢子虫病患者的骨骼肌活检组织进行电子显微镜检查，发现了一种新型的林氏肉孢子虫囊肿。该肉孢子虫囊肿较大，囊壁较厚，有明显的隔膜延伸至囊内，其特征是有宽分支的菜花状突起延伸至囊周区域。这种囊肿类型似乎具有高度致病性。除了受感染肌纤维的肌原纤维完全溶解外，相邻肌纤维出现分层，肌节方向紊乱，Z带排列和弯曲异常，囊周区域的T和L肌原纤维模式消失。检测到了肌炎的特征，如存在丰富的溶酶体结构、肌原纤维排列紊乱和糖原形成。这些细胞致病迹象显然归因于囊壁的结构特征。这些发现不仅否定了与人体肉孢子虫病相关的病理状况是偶然的这一概念，还强调了电子显微镜在根据肉孢子虫形态学表达的致病特性进行相关分型方面的价值。
