巯基试剂对体外胰腺胰高血糖素分泌的影响。
Effects of sulphydryl reagents on pancreatic glucagon secretion in vitro.
作者信息
Hahn H J, Keilacker H, Butter R, Ziegler B
出版信息
Endokrinologie. 1978 Mar;71(3):286-92.
The effect of sulphydryl reagents on glucagon secretion of isolated Wistar rats islets was studied. Chloromercuribenzene-p-sulphonic acid (CMBS) is a strong stimulator of glucagon secretion, whereas 5,5'-dithiobis (2-nitrobenzoic acid) (DTNB) markedly inhibited the hormone release. The effect of CMBS could not be suppressed by 20 mM glucose, but in the presence of 1 mM 4-acetamido-4'-isothiocyano-stilbene-2,2'-disulphonic acid (SITS), and is independent of the glucagon content of islets. The results let us assume that sulphydryl-groups of pancreatic A-cells are involved in the regulation of glucagon secretion.
研究了巯基试剂对分离的Wistar大鼠胰岛胰高血糖素分泌的影响。对氯汞苯磺酸（CMBS）是胰高血糖素分泌的强刺激剂，而5,5'-二硫代双（2-硝基苯甲酸）（DTNB）则显著抑制激素释放。20 mM葡萄糖不能抑制CMBS的作用，但在1 mM 4-乙酰氨基-4'-异硫氰基芪-2,2'-二磺酸（SITS）存在的情况下，其作用与胰岛中胰高血糖素的含量无关。这些结果使我们推测胰腺A细胞的巯基参与了胰高血糖素分泌的调节。
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