钙过敏症：综述
Calciphylaxis: a review.
作者信息
Bhambri Avani, Del Rosso James Q
机构信息
Dr. Bhambri is Dermatology Resident, UCLA Division of Dermatology, Los Angeles, California.
出版信息
J Clin Aesthet Dermatol. 2008 Jul;1(2):38-41.
Abstract
Calciphylaxis is a condition involving vascular calcification and cutaneous necrosis. The mortality rate is high, with more than 50 percent of patients dying within one year of diagnosis. The exact pathogenesis of calciphylaxis is unclear. Lower extremities are most commonly involved. Intravascular calcium deposition in the media of the dermal and subcutaneous arterioles is the diagnostic histopathologic feature seen. Treatment options include wound care, surgical debridement, sodium thiosulfate, bisphosphonates, and hyperbaric oxygen.
摘要
钙过敏是一种涉及血管钙化和皮肤坏死的病症。死亡率很高，超过50%的患者在确诊后一年内死亡。钙过敏的确切发病机制尚不清楚。下肢最常受累。真皮和皮下小动脉中层的血管内钙沉积是所见的诊断性组织病理学特征。治疗选择包括伤口护理、手术清创、硫代硫酸钠、双膦酸盐和高压氧。
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