Wright J J, Gunter K C, Mitsuya H, Irving S G, Kelly K, Siebenlist U
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Science. 1990 May 4;248(4955):588-91. doi: 10.1126/science.2110381.
Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation.
人类T细胞白血病病毒I型和II型（HTLV）编码的基因产物通过反式激活细胞增殖所需基因（可能包括转录调节因子）来介导细胞转化。通过寻找可能控制细胞增殖的因子，发现了一个锌指基因（225），该基因在所检测的所有HTLV-I或HTLV-II转化细胞系中组成性表达，而在正常T细胞中，它仅在有丝分裂原刺激后短暂表达。225基因在两个HTLV-I转化的辅助性T细胞克隆中也组成性表达，但在亲代细胞系中不表达。因此，这种在逆转录病毒感染细胞中异常表达的假定细胞转录因子可能在细胞转化中起作用。
