McConnell I, Klein G, Lint T F, Lachmann P J
Eur J Immunol. 1978 Jul;8(7):453-8. doi: 10.1002/eji.1830080702.
Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV-negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversion and consumption of alternative pathway activity in the supernatant serum. By contrast, EBV-positive sublines derived by in vitro EBV conversion of EBV-negative parental lines produce considerable activation of the alternative pathway. This membrane-associated complement-activating mechanism reflects an EBV-induced membrane change in these cells and may provide a mechanism whereby EBV-transformed cells are controlled in vivo.
人类B细胞淋巴瘤细胞系激活替代补体途径与细胞基因组中存在爱泼斯坦-巴尔病毒（EBV）相关。EBV阴性的B细胞淋巴瘤细胞系产生的替代途径激活很少，这通过细胞表面C3沉积或上清血清中替代途径活性的C3转化和消耗来衡量。相比之下，通过体外将EBV阴性亲代细胞系转化为EBV阳性的亚系会产生相当程度的替代途径激活。这种膜相关的补体激活机制反映了EBV诱导的这些细胞的膜变化，并且可能提供一种在体内控制EBV转化细胞的机制。
