Department of Medicine, University of Illinois at Chicago, 1819 W. Polk Street, M/C 797, Chicago, IL, USA.
Curr Atheroscler Rep. 2011 Feb;13(1):88-94. doi: 10.1007/s11883-010-0146-z.
Various alterations of lipid homeostasis have a significant role in the pathophysiology of the artherosclerotic process. The effects of usual lipid-lowering agents such as statins, fibrates, or niacin are well known, but other endocrine therapeutic agents could also affect the blood levels of various lipoproteins and, in turn, influence atheroma formation. In this review, we attempt to summarize the effect of several hormonal and non-hormonal endocrine agents on lipid metabolism, including insulin, thyroid hormone, sex hormones, glucocorticoids, growth hormone, and several anti-diabetic agents.
各种脂质稳态的改变在动脉粥样硬化过程的病理生理学中起着重要作用。常用的降脂药物如他汀类、贝特类或烟酸的作用已众所周知,但其他内分泌治疗药物也可能影响各种脂蛋白的血浓度,并进而影响动脉粥样斑块的形成。在这篇综述中,我们试图总结几种激素和非激素内分泌药物对脂代谢的影响,包括胰岛素、甲状腺激素、性激素、糖皮质激素、生长激素和几种抗糖尿病药物。