Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Mol Carcinog. 2011 Mar;50(3):189-98. doi: 10.1002/mc.20704. Epub 2010 Nov 23.
The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix-distorting DNA lesions. Several polymorphisms of XPC gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of XPC Lys939Gln (A/C), Ala499Val (C/T), and PAT (-/+) polymorphisms with CRC risk in a population-based case-control study which included 421 CRC patients and 845 controls. For Lys939Gln, the CC genotype was associated with a significantly increased risk of CRC (odds ratio (OR)=1.5; 95% confidence interval (CI)=1.0-2.2) compared with the AA genotype. The subjects with PAT +/+ genotype had a significantly increased risk of CRC (OR=1.5; 95% CI=1.0-2.3), compared with those with PAT-/- genotype. Though no significant association between Ala499Val and CRC risk was observed, we found that individuals carrying the CT+TT genotypes showed a significantly decreased risk of rectal cancer (OR=0.7; 95% CI=0.5-1.0). Additionally, the haplotype C+C was associated with a significantly increased CRC risk (OR=1.3; 95% CI=1.0-1.6), compared with the most common haplotype A-T. Further, individuals with four or more risk alleles exhibited a significantly increased risk of CRC (OR=1.4; 95% CI=1.0-2.0), with a significant gene-dosage effect (P for trend=0.038). Besides, never tea drinking was associated with a significantly increased risk of CRC (OR=2.3; 95% CI=1.7-3.3). Our results suggest that the XPC polymorphisms may modulate CRC susceptibility independently or jointly, and tea drinking has a protective effect on CRC.
着色性干皮病互补组 C（XPC）负责去除体积庞大、扭曲双螺旋的 DNA 损伤。XPC 基因的几个多态性可能调节结直肠癌（CRC）的易感性。我们在一项基于人群的病例对照研究中评估了 XPC Lys939Gln（A/C）、Ala499Val（C/T）和 PAT（-/+）多态性与 CRC 风险的关联，该研究包括 421 例 CRC 患者和 845 例对照。对于 Lys939Gln，与 AA 基因型相比，CC 基因型与 CRC 的风险显著增加（比值比（OR）=1.5；95%置信区间（CI）=1.0-2.2）。与 PAT-/-基因型相比，PAT +/+ 基因型的受试者患 CRC 的风险显著增加（OR=1.5；95% CI=1.0-2.3）。尽管未观察到 Ala499Val 与 CRC 风险之间存在显著关联，但我们发现携带 CT+TT 基因型的个体患直肠癌的风险显著降低（OR=0.7；95% CI=0.5-1.0）。此外，与最常见的 haplotype A-T 相比，C+C 单体型与 CRC 风险显著增加相关（OR=1.3；95% CI=1.0-1.6）。此外，携带四个或更多风险等位基因的个体 CRC 风险显著增加（OR=1.4；95% CI=1.0-2.0），且存在显著的基因剂量效应（P 趋势=0.038）。此外，从不饮茶与 CRC 风险显著增加相关（OR=2.3；95% CI=1.7-3.3）。我们的结果表明，XPC 多态性可能独立或共同调节 CRC 的易感性，饮茶对 CRC 具有保护作用。
