Altaeva E G, Ogneva I V, Shekman B S
Tsitologiia. 2010;52(9):770-5.
In this study, it was shown that calcium levels in the fibers of m. soleus of Mongolian gerbils after one day of unloading increased four and a half times in comparison with the control. In rats, the situation differed: 2.8 times increase after the 1st day of hypogravity persisted until the 3rd day and then calcium levels slightly decreased to the 12th day. However, the base concentrations of calcium in the control group of gerbils were significantly lower than in control rats, thus there was larger shift of this parameter during the first day. Probably, this was the reason for an earlier start of the protein phenotype shift in gerbils: statistically significant increase in the number of fibers with "fast" SERCA isoforms was detected after one day of unloading and therefore slow-to-fast shift in myosin phenotype was observed on the 3rd day of unloading. The same changes in rat muscle could be detected only after the 7th and the 12th day, respectively. In both species, there was a tendency to restore their initial parameters to the 12th day but in gerbils it was much more intensive.
在本研究中，结果表明，蒙古沙鼠比目鱼肌纤维中的钙水平在卸载一天后与对照组相比增加了四倍半。在大鼠中，情况有所不同：低重力第1天后钙水平增加2.8倍，这种情况持续到第3天，然后钙水平在第12天略有下降。然而，沙鼠对照组中钙的基础浓度显著低于对照大鼠，因此该参数在第一天的变化幅度更大。这可能是沙鼠蛋白质表型转变较早开始的原因：卸载一天后，检测到具有“快速”SERCA同工型的纤维数量有统计学意义的增加，因此在卸载第3天观察到肌球蛋白表型从慢到快的转变。大鼠肌肉中的相同变化分别仅在第7天和第12天后才能检测到。在这两个物种中，到第12天时都有恢复到初始参数的趋势，但在沙鼠中这种恢复更为强烈。
