Sangraula H, Paudel K R, Sharma M
Department of clinical Pharmacology and Therapeutics, BPKIHS, Dharan, Nepal.
JNMA J Nepal Med Assoc. 2009 Oct-Dec;48(176):335-9.
Polycystic ovarian syndrome is the most common cause of anovulatory infertility and causes menstrual disruption in 5-10% females, and is characterized by insulin resistance, hyperinsulinemia, hyperandrogenism and anovulation. Such factors are responsible for the increased miscarriage and infertility in women with PCOS. Administration of various insulin sensitizing drugs, such as metformin and troglitazone have been shown to decrease serum androgen concentrations and to increase ovulation rates, increase conception and decrease miscarriage in affected women.
多囊卵巢综合征是无排卵性不孕最常见的原因，导致5%-10%的女性月经紊乱，其特征为胰岛素抵抗、高胰岛素血症、高雄激素血症和无排卵。这些因素导致多囊卵巢综合征女性流产和不孕风险增加。使用各种胰岛素增敏药物，如二甲双胍和曲格列酮，已显示可降低血清雄激素浓度、提高排卵率、增加受孕几率并减少受影响女性的流产率。
