相似文献
1
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.
J Med Chem. 2010 Dec 23;53(24):8709-15. doi: 10.1021/jm101101q. Epub 2010 Nov 24.
2
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17.
3
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j.
4
Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. doi: 10.1016/j.bmcl.2009.08.065. Epub 2009 Aug 21.
5
Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics.
Bioorg Med Chem. 2018 Sep 1;26(16):4716-4725. doi: 10.1016/j.bmc.2018.08.010. Epub 2018 Aug 6.
6
Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors.
Int J Mol Sci. 2021 Mar 26;22(7):3444. doi: 10.3390/ijms22073444.
7
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
J Med Chem. 2003 Jan 2;46(1):1-4. doi: 10.1021/jm0255668.
8
Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
J Med Chem. 2001 Nov 8;44(23):3810-20. doi: 10.1021/jm010914b.
9
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.
Bioorg Med Chem Lett. 2008 Jul 1;18(13):3790-3. doi: 10.1016/j.bmcl.2008.05.039. Epub 2008 May 16.
10
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
Eur J Med Chem. 2012 Nov;57:296-301. doi: 10.1016/j.ejmech.2012.09.030. Epub 2012 Sep 29.
引用本文的文献
1
I-Catalyzed Carbonylation of α-Methylene Ketones to Synthesize 1,2-Diaryl Diketones and Antiviral Quinoxalines in One Pot.
ACS Omega. 2021 Dec 21;7(1):1380-1394. doi: 10.1021/acsomega.1c06017. eCollection 2022 Jan 11.
2
Dual Role of Glyoxal in Metal-Free Dicarbonylation Reaction: Synthesis of Symmetrical and Unsymmetrical Dicarbonyl Imidazoheterocycles.
ACS Omega. 2019 Jun 11;4(6):10140-10150. doi: 10.1021/acsomega.9b00716. eCollection 2019 Jun 30.
3
Two birds, one stone: hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition.
Oncotarget. 2018 Feb 23;9(46):27958-27973. doi: 10.18632/oncotarget.24563. eCollection 2018 Jun 15.
4
Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity.
Biochem Biophys Rep. 2015 Nov 19;5:105-110. doi: 10.1016/j.bbrep.2015.11.018. eCollection 2016 Mar.
5
Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.
AAPS J. 2016 Nov;18(6):1391-1405. doi: 10.1208/s12248-016-9962-6. Epub 2016 Aug 5.
6
Regulations of Xenobiotics and Endobiotics on Carboxylesterases: A Comprehensive Review.
Eur J Drug Metab Pharmacokinet. 2016 Aug;41(4):321-30. doi: 10.1007/s13318-016-0326-5.
7
Carboxylesterase inhibitors.
Expert Opin Ther Pat. 2011 Aug;21(8):1159-71. doi: 10.1517/13543776.2011.586339. Epub 2011 May 24.
本文引用的文献
1
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.
J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296.
2
Wacker-type oxidation of alkynes into 1,2-diketones using molecular oxygen.
Org Lett. 2009 Apr 16;11(8):1841-4. doi: 10.1021/ol900344g.
3
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23.
4
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.
Mol Pharmacol. 2007 Mar;71(3):713-23. doi: 10.1124/mol.105.021683. Epub 2006 Dec 13.
5
Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.
Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160.
6
Carboxylesterases--detoxifying enzymes and targets for drug therapy.
Curr Med Chem. 2006;13(9):1045-54. doi: 10.2174/092986706776360969.
7
Practical method for transforming alkynes into alpha-diketones.
J Org Chem. 2006 Jan 20;71(2):826-8. doi: 10.1021/jo051793g.
8
An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine.
Org Lett. 2006 Jan 19;8(2):269-72. doi: 10.1021/ol052663x.
9
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.
J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196.
10
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j.
Zotero 插件