将炔烃转化为α-二酮的实用方法。

Practical method for transforming alkynes into alpha-diketones.

作者信息

Wan Zhonghui, Jones Chauncey D, Mitchell David, Pu John Y, Zhang Tony Y

机构信息

Global Chemical Process Research and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

出版信息

J Org Chem. 2006 Jan 20;71(2):826-8. doi: 10.1021/jo051793g.

DOI:10.1021/jo051793g

PMID:16409004

Abstract

[reaction: see text] Oxidation of alkynes to alpha-dicarbonyl derivatives through a convenient one-pot procedure via a Brønsted acid-promoted "hydration" and a DMSO-based oxidation sequence has been achieved in high yields. The scope and limitations of the reaction have also been investigated.

摘要

[反应：见正文] 通过一种简便的一锅法，经由布朗斯特酸促进的“水合”以及基于二甲亚砜的氧化序列，已实现将炔烃高产率地氧化为α-二羰基衍生物。该反应的适用范围和局限性也已得到研究。