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含抗生素的骨水泥间隔物治疗创伤后感染性骨不连及上肢骨缺损

Cement spacers with antibiotics for the treatment of posttraumatic infected nonunions and bone defects of the upper extremity.

作者信息

Allende Christian

机构信息

Department of Upper Extremity and Reconstructive Surgery, Hospital Nacional de Clínicas-Sanatorio Allende, Universidad Nacional de Córdoba, Córdoba, Argentina.

出版信息

Tech Hand Up Extrem Surg. 2010 Dec;14(4):241-7. doi: 10.1097/BTH.0b013e3181f42bd3.

Abstract

Treatment of patients with posttraumatic infected nonunions or highly contaminated open fractures with segmental bone loss of the long bones of the upper extremity is demanding. The use of a 2-stage reconstruction technique, being the first stage characterized by thorough debridement, copious lavage, soft tissue coverage, and placement of a cement spacer with antibiotics at the infected site, and the second stage by cement spacer removal, internal fixation, and placement of bone graft with local antibiotics, is presented. We carried out this technique in 20 cases, in 12 cases the cement was molded to fit the defect and placed as a solid interposition mass, in 3 cases it was placed lateral to the affected bone, and in the remaining 5 cases a Rush nail covered with a cement mantle was used. Follow-up averaged 18 months. All nonunions and fractures healed after an average of 5 months. Disabilities of the arm, shoulder, and hand (DASH) score at last follow-up in nonunions averaged 14 points and 21 points in bone losses. Although generally 2 surgical procedures are needed, 1 to cure or prevent infection and another to achieve bony union, this approach for complex open fractures with segmental bone loss and for infected nonunions of the long bones of the upper extremity represents a valid treatment alternative.

摘要

治疗上肢长骨创伤后感染性骨不连或污染严重的开放性骨折且伴有节段性骨缺损的患者具有挑战性。本文介绍了一种两阶段重建技术,第一阶段的特点是彻底清创、大量冲洗、软组织覆盖以及在感染部位放置含抗生素的骨水泥间隔物,第二阶段则是取出骨水泥间隔物、进行内固定并放置含局部抗生素的骨移植材料。我们对20例患者实施了该技术,其中12例将骨水泥塑形以适应缺损并作为实体置入物放置,3例将其放置在患骨外侧,其余5例使用覆盖有骨水泥套的Rush钉。平均随访18个月。所有骨不连和骨折平均在5个月后愈合。骨不连患者末次随访时的上肢、肩部和手部功能障碍(DASH)评分平均为14分,骨缺损患者为21分。尽管通常需要进行两次外科手术,一次用于治愈或预防感染,另一次用于实现骨愈合,但这种治疗上肢长骨节段性骨缺损的复杂开放性骨折和感染性骨不连的方法是一种有效的治疗选择。

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