Skala Christine Elisabeth, Petry Ilka Brigitte, Albrich Stefan, Puhl Alexander, Naumann Gert, Koelbl Heinz
Department of Obstetrics and Gynecology, University Medical Center, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.
Int Urogynecol J. 2011 Jun;22(6):705-12. doi: 10.1007/s00192-010-1327-6. Epub 2010 Nov 24.
This study evaluates the expression of estrogen receptor (ER) isoforms alpha (α) and beta (β) and progesterone receptor (PR) in vaginal and periurethral tissue in women with genital prolapse in relation to genital and lower urinary tract symptoms (LUTS).
Forty-seven postmenopausal women without systemic estrogen therapy underwent pelvic organ prolapse quantification and urodynamic assessment. LUTS were evaluated by CATI questionnaire. Biopsies from vaginal and periurethral tissue were obtained during prolapse surgery. The steroid receptor gene expression was measured by RT-PCR.
The expression of PR in periurethral and ER β in vaginal tissue varied with prolapse extent. Nulliparous women showed a significantly higher expression of PR in periurethral tissue. Women with a positive stress test and those with overactive bladder symptoms showed a significantly lower amount of PR in vaginal tissue.
Changes in PR expression in vaginal or periurethral tissue might be a marker of structural and endocrine changes.
本研究评估雌激素受体（ER）α和β亚型以及孕激素受体（PR）在生殖器脱垂女性阴道和尿道周围组织中的表达，并将其与生殖器及下尿路症状（LUTS）相关联。
47名未接受全身雌激素治疗的绝经后女性接受了盆腔器官脱垂量化和尿动力学评估。通过CATI问卷评估LUTS。在脱垂手术期间获取阴道和尿道周围组织的活检样本。通过逆转录聚合酶链反应（RT-PCR）测量类固醇受体基因表达。
尿道周围组织中PR的表达以及阴道组织中ERβ的表达随脱垂程度而变化。未生育女性尿道周围组织中PR的表达显著更高。压力试验阳性的女性以及有膀胱过度活动症状的女性阴道组织中PR的含量显著更低。
阴道或尿道周围组织中PR表达的变化可能是结构和内分泌变化的一个标志。
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