α受体阻滞剂、单纯体外磁刺激及联合应用治疗女性膀胱出口梗阻的比较
Comparison of alpha-blocker, extracorporeal magnetic stimulation alone and in combination in the management of female bladder outlet obstruction.
作者信息
Koh Jun Sung, Kim Su Jin, Kim Hyo Sin, Kim Joon Chul
机构信息
Department of Urology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 2, Sosa-dong, Wonmi-gu, Bucheon-si, Kyunggi-do, South Korea.
出版信息
Int Urogynecol J. 2011 Jul;22(7):849-54. doi: 10.1007/s00192-010-1322-y. Epub 2010 Nov 25.
INTRODUCTION AND HYPOTHESIS
To determine the effects of alpha-blocker, extracorporeal magnetic innervations (ExMI) alone and combination treatment on female bladder outlet obstruction (BOO).
METHODS
Sixty women with BOO were divided into three groups according to the treatment. After 3 months, the clinical outcomes were evaluated by clinical examination, international prostatic symptom score (IPSS), quality of life (QOL), 3-day voiding diary, uroflowmetry and post-void residual.
RESULTS
At 3 months, symptom improvement was 52.6% in alpha-blocker monotherapy (group I), 50.0% in ExMI monotherapy (group II), and 57.1% in combination therapy (group III). Maximum flow rate increased and total IPSS decreased significantly in all groups (p < 0.05). Storage symptom subscore was more reduced in groups II and III and QOL improved significantly in group III (p < 0.05)
CONCLUSIONS
This study demonstrates that both alpha-blocker and ExMI were effective in female BOO, and ExMI may be more effective for improving storage symptoms.
引言与假设
确定α受体阻滞剂、体外磁刺激神经调节（ExMI）单独治疗及联合治疗对女性膀胱出口梗阻（BOO）的影响。
方法
60例BOO女性患者按治疗方法分为三组。3个月后，通过临床检查、国际前列腺症状评分（IPSS）、生活质量（QOL）、3天排尿日记、尿流率测定和排尿后残余尿量评估临床疗效。
结果
3个月时，α受体阻滞剂单药治疗组（I组）症状改善率为52.6%，ExMI单药治疗组（II组）为50.0%，联合治疗组（III组）为57.1%。所有组的最大尿流率均增加，总IPSS显著降低（p<0.05）。II组和III组的储尿期症状评分降低更多，III组的QOL显著改善（p<0.05）。
结论
本研究表明，α受体阻滞剂和ExMI对女性BOO均有效，且ExMI可能对改善储尿期症状更有效。
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