荷瘤小鼠与用单克隆抗独特型抗体免疫的小鼠的抑制性T因子比较。
Comparison of T suppressor factors from tumour-bearing mice and mice immunized with a monoclonal anti-idiotypic antibody.
作者信息
Greer J M, Halliday W J
机构信息
Department of Microbiology, University of Queensland, Brisbane, Australia.
出版信息
Cancer Immunol Immunother. 1990;31(3):151-6. doi: 10.1007/BF01744729.
Certain dosage schedules of a monoclonal anti-idiotypic antibody (related to a murine bladder carcinoma) were found to induce suppressor factor production by syngeneic mice. This suppressor factor resembled the factor from tumour-bearing mice with respect to idiotype specificity, possession of molecular markers (reactive with anti-IJ and B16G antibodies) and production by Lyt2+IJ+ T cells in spleen cell cultures. The two factors differed with respect to Igh restriction in an in vitro assay (leucocyte adherence inhibition) and ability to suppress the induction of delayed-type hypersensitivity to tumour antigen.
已发现，（与鼠膀胱癌相关的）单克隆抗独特型抗体的某些给药方案可诱导同基因小鼠产生抑制因子。就独特型特异性、拥有分子标记（与抗-IJ和B16G抗体反应）以及在脾细胞培养物中由Lyt2 + IJ + T细胞产生而言，这种抑制因子类似于荷瘤小鼠产生的因子。在体外试验（白细胞黏附抑制）中，这两种因子在免疫球蛋白重链（Igh）限制方面存在差异，并且在抑制对肿瘤抗原的迟发型超敏反应诱导方面的能力也有所不同。
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