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荷瘤小鼠与用单克隆抗独特型抗体免疫的小鼠的抑制性T因子比较。

Comparison of T suppressor factors from tumour-bearing mice and mice immunized with a monoclonal anti-idiotypic antibody.

作者信息

Greer J M, Halliday W J

机构信息

Department of Microbiology, University of Queensland, Brisbane, Australia.

出版信息

Cancer Immunol Immunother. 1990;31(3):151-6. doi: 10.1007/BF01744729.

DOI:10.1007/BF01744729
PMID:2110863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038534/
Abstract

Certain dosage schedules of a monoclonal anti-idiotypic antibody (related to a murine bladder carcinoma) were found to induce suppressor factor production by syngeneic mice. This suppressor factor resembled the factor from tumour-bearing mice with respect to idiotype specificity, possession of molecular markers (reactive with anti-IJ and B16G antibodies) and production by Lyt2+IJ+ T cells in spleen cell cultures. The two factors differed with respect to Igh restriction in an in vitro assay (leucocyte adherence inhibition) and ability to suppress the induction of delayed-type hypersensitivity to tumour antigen.

摘要

已发现，（与鼠膀胱癌相关的）单克隆抗独特型抗体的某些给药方案可诱导同基因小鼠产生抑制因子。就独特型特异性、拥有分子标记（与抗-IJ和B16G抗体反应）以及在脾细胞培养物中由Lyt2 + IJ + T细胞产生而言，这种抑制因子类似于荷瘤小鼠产生的因子。在体外试验（白细胞黏附抑制）中，这两种因子在免疫球蛋白重链（Igh）限制方面存在差异，并且在抑制对肿瘤抗原的迟发型超敏反应诱导方面的能力也有所不同。

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引用本文的文献

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Cancer Immunol Immunother. 1991;33(3):171-6. doi: 10.1007/BF01756138.

本文引用的文献

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T-T hybridoma product specifically suppresses tumor immunity.T-T杂交瘤产物可特异性抑制肿瘤免疫。
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Characterization of a monoclonal antibody directed to a T cell suppressor factor.
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Genetics, expression, and function of idiotypes.独特型的遗传学、表达及功能
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Inhibition of tumor growth by monoclonal anti-I-J antibodies.单克隆抗I-J抗体对肿瘤生长的抑制作用。
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Regulation of cell-mediated immunologic reactivity to Moloney murine sarcoma virus-induced tumors. II. Nature of blocking and unblocking factors in serum.对莫洛尼氏鼠肉瘤病毒诱导肿瘤的细胞介导免疫反应性的调节。II. 血清中封闭和解除封闭因子的性质。
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Cellular origin of blocking factors from cultured spleen cells of tumor-bearing mice.荷瘤小鼠培养脾细胞中封闭因子的细胞起源
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Further characterization of the cells involved in leukocyte adherence inhibition with murine tumor extracts.对参与小鼠肿瘤提取物白细胞黏附抑制作用的细胞进行进一步表征。
Cell Immunol. 1982 Jan 15;66(2):394-406. doi: 10.1016/0008-8749(82)90189-7.
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J Natl Cancer Inst. 1969 Jul;43(1):141-50.
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Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas.莫洛尼病毒诱导的小鼠肉瘤细胞免疫及其血清介导抑制作用的研究。
Int J Cancer. 1969 Sep 15;4(5):587-600. doi: 10.1002/ijc.2910040503.

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