Vaninbroukx I, Van Calster J, Van Calster B, Spileers W, Verhaegen J, Stalmans P
Department of Ophthalmology University Hospitals Leuven, Belgium.
Bull Soc Belge Ophtalmol. 2010(315):9-12.
To determine the efficacy of preoperative eye disinfection by comparing antibiotic and antiseptic eye drops.
Prospective, randomized double-masked comparative study with three study arms: untreated, antibiotic treated and antiseptic treated.
Patients that were scheduled for vitrectomy were asked to use an antibiotic or antiseptic eye drop 4 times a day, 5 days before the surgery. Conjunctival smear was cultured at the onset of the surgery. Culture results for each study arm were compared.
Comparable results were found in the patients treated with an antibiotic or antiseptic eye drop.
Since an antiseptic eye drop will cause less bacterial resistance than an antibiotic eye drop, and both treatments have a similar antibacterial effect, this study indicates that prophylactic antiseptic eye drops may be preferred over antibiotic treatment, when prophylaxis is needed.
通过比较抗生素眼药水和抗菌眼药水来确定术前眼部消毒的效果。
前瞻性、随机双盲对照研究，分为三个研究组：未治疗组、抗生素治疗组和抗菌剂治疗组。
计划进行玻璃体切除术的患者被要求在手术前5天每天使用4次抗生素或抗菌眼药水。手术开始时采集结膜涂片进行培养。比较每个研究组的培养结果。
使用抗生素或抗菌眼药水治疗的患者结果相当。
由于抗菌眼药水比抗生素眼药水产生的细菌耐药性更少，且两种治疗方法具有相似的抗菌效果，因此本研究表明，在需要预防时，预防性使用抗菌眼药水可能比抗生素治疗更可取。
