Furuya T
Department of Anatomy, Tokyo Medical College, Japan.
Biol Reprod. 1990 Mar;42(3):491-8. doi: 10.1095/biolreprod42.3.491.
When rats were unilaterally castrated at 20, 30, and 40 days of age, only those rats hemicastrated at 40 days showed compensatory hypertrophy of the interstitial tissue and Leydig cells when killed 30 days after hemicastration. At the time of death, volume densities of interstitial tissue, Leydig cells, and vascular components were greater in 70-day-old hemicastrated rats than in intact rats of the same age. The total number of Leydig cells per testis in hemicastrated and intact rats was always the same at any age. Estimated Leydig cell volume in 70-day-old rats was twice that in intact rats. By contrast, the testes of 50- and 60-day-old rats at the time of death displayed essentially the same morphological features, regardless of whether animals were hemicastrated. The concentration of plasma testosterone was higher in 50-day-old controls than in hemicastrated rats. Seventy-day-old hemicastrated rats showed higher levels of plasma testosterone than controls. The level of plasma dihydrotestosterone in 60- and 70-day-old hemicastrated rats exceeded that in the controls. A significant increase in follicle-stimulating hormone was noted in 50- and 70-day-old hemicastrated rats compared to normal rats, while levels of luteinizing hormone were basically the same. The increase in Leydig cell volume, interstitial tissue volume, vascular component volume, and plasma testosterone level caused by hemicastration at 40 days of age differed from that at 20 and 30 days of age.
在20日龄、30日龄和40日龄时对大鼠进行单侧去势，只有40日龄时进行半去势的大鼠在半去势30天后处死时显示出间质组织和莱迪希细胞的代偿性肥大。在死亡时，70日龄半去势大鼠的间质组织、莱迪希细胞和血管成分的体积密度高于同年龄的完整大鼠。在任何年龄，半去势大鼠和完整大鼠每个睾丸中莱迪希细胞的总数始终相同。70日龄大鼠的估计莱迪希细胞体积是完整大鼠的两倍。相比之下，50日龄和60日龄大鼠在死亡时的睾丸显示出基本相同的形态特征，无论动物是否进行了半去势。50日龄对照组大鼠的血浆睾酮浓度高于半去势大鼠。70日龄半去势大鼠的血浆睾酮水平高于对照组。60日龄和70日龄半去势大鼠的血浆双氢睾酮水平超过对照组。与正常大鼠相比，50日龄和70日龄半去势大鼠的促卵泡激素显著增加，而黄体生成素水平基本相同。40日龄时半去势引起的莱迪希细胞体积、间质组织体积、血管成分体积和血浆睾酮水平的增加与20日龄和30日龄时不同。
