皮肤黑色素瘤的分期与预后
Staging and prognosis of cutaneous melanoma.
作者信息
Dickson Paxton V, Gershenwald Jeffrey E
机构信息
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, TX 77030, USA.
出版信息
Surg Oncol Clin N Am. 2011 Jan;20(1):1-17. doi: 10.1016/j.soc.2010.09.007.
Staging of cutaneous melanoma continues to evolve through identification and rigorous analysis of potential prognostic factors. In 1998, the American Joint Committee on Cancer (AJCC) Melanoma Staging Committee developed the AJCC melanoma staging database, an international integrated compilation of prospectively accumulated melanoma outcome data from several centers and clinical trial cooperative groups. Analysis of this database resulted in major revisions to the TNM staging system reflected in the sixth edition of the AJCC Cancer Staging Manual published in 2002. More recently, the committee's analysis of an updated melanoma staging database, including prospective data on more than 50,000 patients, led to staging revisions adopted in the seventh edition of the AJCC Cancer Staging Manual published in 2009. This article highlights these revisions, reviews relevant prognostic factors and their impact on staging, and discusses emerging tools that will likely affect future staging systems and clinical practice.
皮肤黑色素瘤的分期通过对潜在预后因素的识别和严格分析不断发展。1998年，美国癌症联合委员会（AJCC）黑色素瘤分期委员会开发了AJCC黑色素瘤分期数据库，这是一个国际综合性汇编，收录了来自多个中心和临床试验合作组的前瞻性积累的黑色素瘤结局数据。对该数据库的分析导致了TNM分期系统的重大修订，这些修订反映在2002年出版的《AJCC癌症分期手册》第六版中。最近，该委员会对一个更新的黑色素瘤分期数据库进行了分析，其中包括50000多名患者的前瞻性数据，这导致了2009年出版的《AJCC癌症分期手册》第七版中采用的分期修订。本文重点介绍了这些修订，回顾了相关预后因素及其对分期的影响，并讨论了可能影响未来分期系统和临床实践的新兴工具。
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