Department of Clinical Biochemistry, Centre of Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
Acta Paediatr. 2011 Apr;100(4):543-9. doi: 10.1111/j.1651-2227.2010.02100.x. Epub 2010 Dec 17.
To assess the incidence rates (IR), clinical characteristics, risk factors, treatment and outcomes of paediatric arterial ischaemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT).
Using population-based, nationwide medical registries, we identified all patients aged 0-18 years at the time of hospitalization with first-ever AIS and/or CSVT in Denmark between 1994 and 2006. Medical records were retrieved and reviewed.
We identified 211 patients with AIS and 40 patients with CSVT corresponding to IRs of 1.33 (95% CI 1.16-1.52) and 0.25 (95% CI 0.19-0.34) per 100,000 person-years, respectively. The IRs peaked in infancy (<1 year) for both AIS and CSVT with an additional peak among adolescents (15-18 years) for CSVT. The IR of AIS increased 3.9% per year (p=0.036), whereas no changes were found for CSVT. In total, 48.2% of the patients received antithrombotic treatment; no major complications were observed. All-cause and thrombosis-related 30-day case fatality ratios were 3.6% and 2.4%, respectively; neurological sequelae were found in 56.2% of patients.
The IR of AIS was highest in infants and had increased with 3.9% annually during the observation period. The IR of CSVT had an additional peak in adolescence and remained unchanged over time.
评估儿科动脉缺血性脑卒中（AIS）和脑静脉窦血栓形成（CSVT）的发病率（IR）、临床特征、危险因素、治疗和结局。
使用基于人群的全国性医疗登记处，我们在 1994 年至 2006 年期间确定了丹麦所有在住院时患有首次 AIS 和/或 CSVT 的 0-18 岁患者。检索并审查了病历。
我们确定了 211 例 AIS 患者和 40 例 CSVT 患者，IR 分别为 1.33（95%CI 1.16-1.52）和 0.25（95%CI 0.19-0.34）/100,000 人年。AIS 和 CSVT 的 IR 在婴儿期（<1 岁）最高，CSVT 青少年（15-18 岁）中另有一个高峰。AIS 的 IR 每年增加 3.9%（p=0.036），而 CSVT 则没有变化。总共有 48.2%的患者接受了抗血栓治疗；未观察到重大并发症。所有原因和血栓相关的 30 天病死率分别为 3.6%和 2.4%；56.2%的患者存在神经后遗症。
AIS 的 IR 在婴儿期最高，在观察期间每年增加 3.9%。CSVT 的 IR 在青春期有一个额外的高峰，并且随着时间的推移保持不变。
