Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
Colorectal Dis. 2011 May;13(5):e71-8. doi: 10.1111/j.1463-1318.2010.02530.x.
Observed associations of alcohol with colorectal cancer are prone to distortion by confounding and reverse causation. A Mendelian randomization approach provides an unbiased estimate of the association using the aldehyde dehydrogenase 2 (ALDH2) variant as a surrogate of alcohol exposure.
A meta-analysis was performed to assess the association between the ALDH2 genotype and colorectal neoplasia, using the ALDH2 genotype as a marker of alcohol intake.
The pooled odds ratio (OR) of colorectal neoplasia was 1.31 (95%CI, 1.01-1.70) for the Glu/Glu vs the Lys/Lys genotype. There was no evidence of interstudy heterogeneity (P = 0.12, I² = 42.7). The overall risk for Glu/Lys heterozygotes relative to Lys/Lys homozygotes (under a fixed-effects model) was 1.13 (95%CI, 0.86-1.48). There was no evidence of publication bias for Glu/Glu or Glu/Lys analysis.
The result supports the role of alcohol in colorectal carcinogenesis based on a Mendelian randomization approach.
观察到的酒精与结直肠癌之间的关联容易受到混杂和反向因果关系的扭曲。孟德尔随机化方法使用乙醛脱氢酶 2（ALDH2）变体作为酒精暴露的替代物，提供了对关联的无偏估计。
进行荟萃分析，使用 ALDH2 基因型作为酒精摄入量的标志物，评估 ALDH2 基因型与结直肠肿瘤之间的关联。
Glu/Glu 与 Lys/Lys 基因型相比，结直肠肿瘤的合并优势比（OR）为 1.31（95%CI，1.01-1.70）。没有研究间异质性的证据（P = 0.12，I² = 42.7）。与 Lys/Lys 纯合子相比，Glu/Lys 杂合子的总体风险（在固定效应模型下）为 1.13（95%CI，0.86-1.48）。Glu/Glu 或 Glu/Lys 分析均未发现发表偏倚的证据。
该结果基于孟德尔随机化方法支持酒精在结直肠癌发生中的作用。
