Simpson J B, Epstein A N, Camardo J S
J Comp Physiol Psychol. 1978 Aug;92(4):581-601. doi: 10.1037/h0077503.
The proposal of the subfornical organ (SFO) as a site of receptors for drinking induced by angiotensin II (AII) was investigated with several mutually confirmatory experiments. Intracranial injections of physiological doses of AII elicited drinking if and only if applied directly to the SFO (Experiment I). Ablation of the SFO selectively (Experiment 2) and permanently (Experiment 4) eliminated drinking elicited by physiological doses of intravenously infused AII. Animals in which SFO had been ablated responded normally to cellular dehydration but reduced responding to the extracellular thirsts of beta-adrenergic activation and hyperoncotic colloid dialysis (Experiment 3). Infusion of saralasin, an AII antagonist, directly into the SFO selectively and reversibly antagonized intravenous AII drinking (Experiment 5). The hypothesis that the SFO contains dipsogenic receptors for circulating AII is strongly supported.
通过多个相互印证的实验，对将穹窿下器（SFO）作为血管紧张素II（AII）诱导饮水的受体部位这一假说进行了研究。仅当将生理剂量的AII直接注射到SFO时，颅内注射该剂量的AII才会引发饮水行为（实验I）。选择性地（实验2）和永久性地（实验4）损毁SFO，可消除生理剂量静脉注射AII所引发的饮水行为。SFO被损毁的动物对细胞脱水反应正常，但对β-肾上腺素能激活和高渗胶体透析所导致的细胞外口渴反应减弱（实验3）。将AII拮抗剂沙拉新直接注入SFO，可选择性且可逆地拮抗静脉注射AII所引发的饮水行为（实验5）。SFO含有循环AII的致渴受体这一假说得到了有力支持。
