合成及一些噻唑并苯并咪唑衍生物的体外细胞毒性评价。
Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives.
机构信息
Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.
出版信息
Eur J Med Chem. 2011 Jan;46(1):417-22. doi: 10.1016/j.ejmech.2010.11.014. Epub 2010 Nov 27.
A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.
设计并合成了一种新型噻唑并苯并咪唑衍生物，并评价了它们对 SMMC-7721 和 A549 细胞系的抗肿瘤活性。大多数化合物表现出良好的抗肿瘤活性，化合物 11b 表现出与紫杉醇相当的显著体外抗癌活性。根据获得的实验数据，讨论了这些苯并咪唑衍生物的初步构效关系。
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