Lopatin Iu M, Dronova E P
Kardiologiia. 2010;50(9):15-22.
Aim of this study was to assess clinical and pharmacoeconomic effects of long term use of adrenoblockers in patients with ischemic heart disease (IHD) undergoing coronary artery bypass grafting. Patients with IHD (n=294) were included in open, prospective, randomized clinical trial. The follow up period was 3 years. It was noted that long term use of bisoprolol in comparison with atenolol and metoprolol was characterized by more pronounced increase of exercise tolerance, lower rate of angina recurrence and lower expenses for treatment of patients with IHD.
本研究的目的是评估长期使用肾上腺阻滞剂对接受冠状动脉搭桥术的缺血性心脏病（IHD）患者的临床和药物经济学效果。将IHD患者（n = 294）纳入开放、前瞻性、随机临床试验。随访期为3年。结果发现，与阿替洛尔和美托洛尔相比，长期使用比索洛尔的特点是运动耐量增加更为显著，心绞痛复发率更低，IHD患者的治疗费用更低。
