van den Belt-Dusebout A W Sandra, Aleman Berthe M P, Gietema Jourik A, de Wit Ronald, van 't Veer Mars B, Lugtenburg P J Elly, Krol A D G Stijn, van Leeuwen Floor E
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Afd. Epidemiologie, Amsterdam, the Netherlands.
Ned Tijdschr Geneeskd. 2010;154(45):A2229.
Patients who were treated in the past with radiotherapy or chemotherapy for testicular cancer or Hodgkin lymphoma are at risk of new malignancies and cardiovascular disease on the long run. Two patient groups who were diagnosed in various hospitals in the Netherlands as having testicular cancer and Hodgkin lymphoma in the period 1965-1995 have survived for a mean period of almost 20 years by now. Both patient groups have higher risks of a new malignancy or cardiovascular disease following radiotherapy and/or chemotherapy than the general population or patients treated without or with less intensive radiotherapy or chemotherapy. As recovery of Hodgkin lymphoma is only achieved by a more intensive treatment approach than the treatment approach for testicular cancer, the risks of a new malignancy or cardiovascular disease are considerably higher among survivors of Hodgkin lymphoma than among survivors of testicular cancer. In both patient groups the long-term risks of new malignancies and cardiovascular disease are still raised in both patient groups up to 25 years after treatment. Because of the relatively high risks of late treatment complications, recommendations for follow-up for survivors of testicular cancer and Hodgkin lymphoma are necessary.
过去接受过睾丸癌或霍奇金淋巴瘤放疗或化疗的患者，长期来看有患新发恶性肿瘤和心血管疾病的风险。在1965年至1995年期间，荷兰多家医院诊断出患有睾丸癌和霍奇金淋巴瘤的两组患者，至今平均存活了近20年。与普通人群或接受非强化或低强度放疗或化疗的患者相比，这两组患者在接受放疗和/或化疗后发生新发恶性肿瘤或心血管疾病的风险更高。由于霍奇金淋巴瘤只有通过比睾丸癌更强化的治疗方法才能治愈，因此霍奇金淋巴瘤幸存者发生新发恶性肿瘤或心血管疾病的风险比睾丸癌幸存者高得多。在这两组患者中，治疗后长达25年，新发恶性肿瘤和心血管疾病的长期风险仍然存在。由于晚期治疗并发症的风险相对较高，因此有必要对睾丸癌和霍奇金淋巴瘤幸存者的随访提出建议。
