Bos Annelies M E, Pelinck Marie-José, Dumoulin John C M, Arts Eus G J M, van Echten-Arends Jannie, Simons Arnold H M
Universitair Medisch Centrum Groningen, Afd. Obstetrie & Gynaecologie, the Netherlands.
Ned Tijdschr Geneeskd. 2010;154(45):A2519.
In vitro fertilisation (IVF) usually involves controlled ovarian stimulation (COS). There is now increasing emphasis on methods that make IVF safer and more patient-friendly. Modified natural cycle (MNC)-IVF is an example of this. In MNC-IVF spontaneous ovulation is prevented with a minimal amount of hormones and spontaneous monofollicular growth is supported. As a result, there is no risk of ovarian hyperstimulation syndrome, and the risk of a multiple pregnancy is low. There is a 9.1% chance of a pregnancy after one MNC-cycle and the cumulative pregnancy rate after a maximum of 6 MNC-IVF cycles is 33.4%. The cumulative results of a maximum of 6 MNC-IVF cycles are comparable to those of the first COS-IVF treatment cycle including transfer of cryopreserved embryos produced as a result of the treatment (33.4% versus 37.7%). The risk of a twin pregnancy following MNC-IVF is 0.1%, and 18.3% following COS-IVF. This means that MNC-IVF is a good alternative for COS-IVF.
体外受精（IVF）通常涉及控制性卵巢刺激（COS）。现在越来越强调使IVF更安全且对患者更友好的方法。改良自然周期（MNC）-IVF就是一个例子。在MNC-IVF中，用最少的激素阻止自发排卵，并支持单个卵泡自然生长。因此，不存在卵巢过度刺激综合征的风险，多胎妊娠的风险也很低。一个MNC周期后妊娠几率为9.1%，最多6个MNC-IVF周期后的累积妊娠率为33.4%。最多6个MNC-IVF周期的累积结果与首次COS-IVF治疗周期（包括移植因该治疗产生的冷冻胚胎）的结果相当（33.4%对37.7%）。MNC-IVF后双胎妊娠风险为0.1%，COS-IVF后为18.3%。这意味着MNC-IVF是COS-IVF的一个良好替代方案。
