Schneider J, Matthiesen T
Center of Research, Grünenthal GmbH, Aachen, FRG.
Life Sci. 1990;46(20):1421-6. doi: 10.1016/0024-3205(90)90457-3.
The permanent survival rate of endotoxemic rats was studied. In 40 untreated control rats the survival rate 7 days after the endotoxin administration was 33%. The survival rate was increased to 40% with recombinant human superoxide dismutase (r-HSOD), to 55% (p less than 0.05) with the prostacyclin analogue Taprostene and to 70% (p less than 0.01) with the combination of r-HSOD and Taprostene (20 rats for each treatment group). r-HSOD and Taprostene provide significant and permanent protection in rat endotoxic shock.
研究了内毒素血症大鼠的永久存活率。在40只未经治疗的对照大鼠中，内毒素给药7天后的存活率为33%。重组人超氧化物歧化酶（r-HSOD）使存活率提高到40%，前列环素类似物他前列烯使存活率提高到55%（p<0.05），r-HSOD与他前列烯联合使用使存活率提高到70%（p<0.01）（每个治疗组20只大鼠）。r-HSOD和他前列烯在大鼠内毒素休克中提供了显著且持久的保护作用。
