J Clin Pharmacol. 2011 Dec;51(12):1733-4. doi: 10.1177/0091270010385936. Epub 2010 Nov 30.
Baclofen is a gamma amino butyric acid (GABA) derivative that is a specific agonist at GABA-B receptors. Initially used in the treatment of spasticity, it is now being used in the treatment of alcohol dependence. Although it has several known adverse effects, incidence of rashes developing due to baclofen is very rare, and morbiliform rashes due to baclofen, an exceedingly rare adverse effect, has been reported only once before. We report a case series of 4 patients who developed morbiliform rashes after initiation of baclofen.
巴氯芬是一种γ-氨基丁酸（GABA）衍生物，是 GABA-B 受体的特异性激动剂。最初用于治疗痉挛，现在用于治疗酒精依赖。尽管它有几个已知的不良反应，但由于巴氯芬引起的皮疹发生率非常罕见，而由于巴氯芬引起的麻疹样皮疹是一种极其罕见的不良反应，以前仅报告过一次。我们报告了 4 例患者在开始使用巴氯芬后出现麻疹样皮疹的病例系列。
