精神障碍患者的治疗依从性治疗：随机对照试验。
Treatment adherence therapy in people with psychotic disorders: randomised controlled trial.
机构信息
Erasmus University Medical Center, Department of Psychiatry, Rotterdam, The Netherlands.
出版信息
Br J Psychiatry. 2010 Dec;197(6):448-55. doi: 10.1192/bjp.bp.110.077289.
BACKGROUND
Interventions to improve adherence to treatment in people with psychotic disorders have produced inconclusive results. We developed a new treatment, treatment adherence therapy (TAT), whose intervention modules are tailored to the reasons for an individual's non-adherence.
AIMS
To examine the effectiveness of TAT with regard to service engagement and medication adherence in out-patients with psychotic disorders who engage poorly.
METHOD
Randomised controlled study of TAT v. treatment as usual (TAU) in 109 out-patients. Most outcome measurements were performed by masked assessors. We used intention-to-treat multivariate analyses (Dutch Trial Registry: NTR1159).
RESULTS
Treatment adherence therapy v. TAU significantly benefited service engagement (Cohen's d = 0.48) and medication adherence (Cohen's d = 0.43). Results remained significant at 6-month follow-up for medication adherence. Near-significant effects were also found regarding involuntary readmissions (1.9% v. 11.8%, P = 0.053). Symptoms and quality of life did not improve.
CONCLUSIONS
Treatment adherence therapy helps improve engagement and adherence, and may prevent involuntary admission.
背景
改善精神障碍患者治疗依从性的干预措施并未得出明确的结果。我们开发了一种新的治疗方法，即治疗依从性治疗（TAT），其干预模块是根据个体不依从的原因量身定制的。
目的
研究 TAT 对参与度差的精神障碍门诊患者的服务参与和药物依从性的有效性。
方法
对 109 名参与度差的精神障碍门诊患者进行 TAT 与常规治疗（TAU）的随机对照研究。大多数结果测量均由盲法评估者进行。我们使用意向治疗多变量分析（荷兰试验注册处：NTR1159）。
结果
TAT 与 TAU 相比，服务参与度（Cohen's d = 0.48）和药物依从性（Cohen's d = 0.43）显著提高。药物依从性在 6 个月随访时仍保持显著。关于非自愿入院，也发现了接近显著的效果（1.9%比 11.8%，P = 0.053）。症状和生活质量没有改善。
结论
治疗依从性治疗有助于提高参与度和依从性，并可能预防非自愿入院。
Zotero 插件