Joubert P H, Kruger F J, Pretorius S J
Research Institute for Diseases in a Tropical Environment of South African Medical Research Council, Nelspruit.
Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):100-2. doi: 10.1016/0035-9203(90)90394-t.
The use of intermediate host snails of Schistosoma spp. which are insusceptible to infection has been proposed as a possible method of controlling schistosomiasis. The objective of this approach is to change the susceptibility of natural snail populations from being predominantly susceptible to a non-susceptible state, through the release of refractory snails into natural habitats. In an attempt to determine whether or not such refractory Bulinus africanus populations occur in eastern South Africa, F1 generation snails of populations from 8 different areas were exposed to miracidia hatched from eggs excreted in the urine of schoolchildren infected with Schistosoma haematobium in the Nelspruit district. The proportion of snails successfully infected ranged from 27 to 100%, which revealed considerable genetic heterogeneity amongst populations of the same snail species. One population from Natal could be regarded as partially refractory, while a laboratory population from Durban proved to be 100% susceptible. A completely refractory strain of B. africanus has not yet been identified.
