Infectious Diseases Division, Department of Pediatrics, Montreal Children's Hospital;
Can J Infect Dis Med Microbiol. 2009 Winter;20(4):e173-6. doi: 10.1155/2009/424093.
A case of near-fatal oseltamivir-resistant seasonal influenza A infection in a previously healthy four-year-old boy is reported. This case highlights three important points for physicians: oseltamivir-resistant influenza A (H1N1) has recently emerged in North America; contrary to previously held beliefs, such strains are capable of causing severe disease in healthy children; and given this change in epidemiology, clinicians caring for children with severe seasonal influenza A infection should consider empiric dual therapy with oseltamivir and amantadine.
现报道 1 例先前健康的 4 岁男孩发生近乎致命性奥司他韦耐药季节性甲型流感感染。该病例为临床医生提供 3 点重要信息：北美近期出现奥司他韦耐药甲型流感（H1N1）；与既往观点相反，此类病毒株可导致健康儿童发生严重疾病；鉴于这种流行病学变化，治疗重症季节性甲型流感感染患儿时，临床医生应考虑奥司他韦联合金刚烷胺经验性双药治疗。
