大鼠肝脏中甘氨酸裂解系统的产后发育

Postnatal development of the glycine cleavage system in rat liver.

作者信息

Kalbag S S, Palekar A G

机构信息

Nassau County Medical Center, Department of Pediatrics, State University of New York, East Meadow 11554.

出版信息

Biochem Med Metab Biol. 1990 Apr;43(2):128-32. doi: 10.1016/0885-4505(90)90017-u.

DOI:10.1016/0885-4505(90)90017-u

PMID:2112009

Abstract

The development of the glycine cleavage system was studied in liver mitochondrial extracts from neonatal and adult rats. The enzyme activity in 2-day-old pups was 29.3% of that measured in the adult and was found to increase in an age-dependent manner. Measurement of hepatic free amino acid concentrations at the neonatal ages showed that glycine levels were highest at 2 days and at 14 days were about 48% of those in the 2-day-old pups. Serine levels did not change between the age of 2 and 14 days. A developmental delay in the glycine cleavage system is responsible for the high levels of glycine in the neonatal rat liver.

摘要

对新生大鼠和成年大鼠肝脏线粒体提取物中的甘氨酸裂解系统发育进行了研究。2日龄幼崽的酶活性为成年大鼠测定值的29.3%，且发现其以年龄依赖性方式增加。对新生期肝脏游离氨基酸浓度的测量表明，甘氨酸水平在2日龄时最高，在14日龄时约为2日龄幼崽的48%。丝氨酸水平在2至14日龄之间没有变化。甘氨酸裂解系统的发育延迟是新生大鼠肝脏中甘氨酸水平高的原因。