（±）-马替诺林和（±）-石蚕酰胺的全合成。

Total synthesis of (±)-maistemonine and (±)-stemonamide.

机构信息

State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.

出版信息

Chem Commun (Camb). 2011 Feb 14;47(6):1836-8. doi: 10.1039/c0cc02612c. Epub 2010 Dec 1.

DOI:10.1039/c0cc02612c

PMID:21120242

Abstract

The first total synthesis of polycyclic Stemona alkaloid maistemonine has been achieved. The efficient approach features a stereoselective intramolecular Schmidt reaction, a ketone-ester condensation, and a Reformatsky reaction. Additionally, another Stemona alkaloid stemonamide was divergently synthesized from a common intermediate.

摘要

首次实现了多环重楼生物碱麦司明宁的全合成。该高效方法的特点是立体选择性的分子内施密特反应、酮酯缩合反应和雷福尔马茨基反应。此外，还从一个共同的中间体出发，对另一种重楼生物碱重楼酰胺进行了发散合成。