Beal J A
J Neurocytol. 1978 Aug;7(4):395-403. doi: 10.1007/BF01173987.
Electron microscopic investigation of laminae I-III in the lumbosacral region of the squirrel monkey spinal cord has disclosed possible stages in the morphogenesis of the Hirano body. These bodies occur occasionally in nerve cell bodies and dendrites. They are round to oval in shape, measure up to 2.2 micrometer in diameter and are composed of circular layers of 10 nm filaments. In several instances in the present study, Hirano bodies were observed in close association with the Golgi apparatus. Here Golgi-related vesicles were attached to the external surface of the Hirano bodies. In one instance a cluster of developing Hirano bodies of various sizes was observed. The smaller bodies were located nearest the Golgi apparatus while the larger were further away. In this case several short filaments, which may be precursors of the longer filaments which make up the layers of the inclusion, were observed in the cytoplasm between the Golgi cisternae and the smaller Hirano bodies. These observations suggest that the Golgi apparatus plays a major role in the production of the Hirano body. The significance of the occurrence of these inclusions is discussed.
对松鼠猴脊髓腰骶段I-III层的电子显微镜研究揭示了 Hirano 小体形态发生的可能阶段。这些小体偶尔出现在神经细胞体和树突中。它们呈圆形至椭圆形，直径可达2.2微米，由10纳米细丝的圆形层组成。在本研究的几个实例中，观察到 Hirano 小体与高尔基体密切相关。此处，与高尔基体相关的囊泡附着在 Hirano 小体的外表面。在一个实例中，观察到一群大小各异的正在发育的 Hirano 小体。较小的小体位于最靠近高尔基体的位置，而较大的则较远。在这种情况下，在高尔基体池和较小的 Hirano 小体之间的细胞质中观察到几根短细丝，它们可能是构成包涵体层的较长细丝的前体。这些观察结果表明高尔基体在 Hirano 小体的产生中起主要作用。讨论了这些包涵体出现的意义。
