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[自体脉络膜视网膜色素上皮细胞片移植治疗年龄相关性黄斑变性黄斑下出血]

[Autologous choroidal RPE patch transplantation for submacular hemorrhage in age-related macular degeneration].

作者信息

Stopa Marcin, Rospond-Kubiak Iwona, Rakowicz Piotr, Kociecki Jarosław

机构信息

Z Katedry i Kliniki Okulistyki Uniwersytetu Medycznego w Poznaniu.

出版信息

Klin Oczna. 2010;112(7-9):230-5.

Abstract

PURPOSE

To report autologous choroidal RPE patch transplantation for treatment of submacular hemorrhage in a patients with age related macular degeneration.

MATERIAL AND METHODS

A case report of a patient with sudden vision deterioration due to submacular hemorrhage in AMD. The visual acuity was 5/5 in the right eye and 0.5/50 in the left eye. He was treated with autologous choroidal RPE patch transplantation. Outcome measures included preoperative and postoperative visual acuity at 1, 3, 6 months, duration of hemorrhage, hemorrhage size on preoperative fluorescein angiography and thickness of the subretinal hemorrhagic complex on preoperative and postoperative OCT scans.

RESULTS

Visual acuity improved from 0.5/50 to 5/50 in 6 months follow-up. No major intraoperative and postoperative complications were observed. The perfusion of the graft was confirmed in ICG angiography.

CONCLUSIONS

Autologous choroidal RPE patch transplantation is an effective option for submacular hemorrhage treatment in AMD. Unlike macular translocation, the surgery can be performed even in patients with excellent visual acuity in the fellow eye.

摘要

目的

报告自体脉络膜视网膜色素上皮(RPE)片移植治疗年龄相关性黄斑变性患者黄斑下出血的情况。

材料与方法

报告一例因年龄相关性黄斑变性导致黄斑下出血而突然视力下降的患者。右眼视力为5/5,左眼视力为0.5/50。对其进行了自体脉络膜RPE片移植治疗。观察指标包括术前及术后1、3、6个月的视力、出血持续时间、术前荧光素血管造影显示的出血大小以及术前和术后光学相干断层扫描(OCT)显示的视网膜下出血复合体厚度。

结果

在6个月的随访中,视力从0.5/50提高到了5/50。未观察到重大的术中及术后并发症。吲哚菁绿血管造影(ICG)证实了移植片的灌注。

结论

自体脉络膜RPE片移植是治疗年龄相关性黄斑变性患者黄斑下出血的一种有效选择。与黄斑转位不同,即使对侧眼视力良好的患者也可进行该手术。

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