突尼斯中部海岸地区的小儿尿路结石：根据年龄和性别的结石成分变化

Paediatric urolithiasis in central coast region of Tunisia: changes in stone composition according to age and gender.

作者信息

Alaya Akram, Nouri Abdellatif, Najjar Mohamed Fadhel

机构信息

University Hospital, Department of Biochemistry and Toxicology, 5000 Monastir, Tunisia.

出版信息

Arch Ital Urol Androl. 2010 Sep;82(3):135-9.

PMID:21121429

Abstract

OBJECTIVE

Studies evaluating the influence of age and gender on the distribution of the various types of paediatric urinary calculi are scarce. Aim of our study was to high-light the modification of epidemiological characteristics of this pathology depending on patients' age and gender.

PATIENTS AND METHODS

We present the results of a study based on 205 calculi (from 122 boys and 83 girls) analyzed by infrared spectroscopy between 1993 and 2007. 54.6% of the patients were under 5 years.

RESULTS

Calcium oxalate (CaOx) was the predominant constituent in 54.7% of stones, followed by calcium phosphate and ammonium urate (14.6% each). We found a male preponderance for struvite stones (12.3% vs 1.2%), and an increasing prevalence of calcium oxalate stones with age (42.9% in infants vs 59.3% in older children). Purines stones were observed in 20% of cases, but their prevalence decreases with age (28.6% in infants vs 18.5% in old children).

CONCLUSION

The increase of calcium oxalate stone rate in school age children and the decrease of purines stones confirm the change on the etiology of urolithiasis according to age.

摘要

目的

评估年龄和性别对各类小儿尿路结石分布影响的研究较少。我们研究的目的是突出这种疾病的流行病学特征随患者年龄和性别的变化。

患者与方法

我们展示了一项基于1993年至2007年间通过红外光谱分析的205颗结石（来自122名男孩和83名女孩）的研究结果。54.6%的患者年龄在5岁以下。

结果

草酸钙（CaOx）是54.7%结石的主要成分，其次是磷酸钙和尿酸铵（各占14.6%）。我们发现磷酸镁铵结石男性居多（12.3%对1.2%），草酸钙结石的患病率随年龄增加（婴儿中为42.9%，大龄儿童中为59.3%）。20%的病例观察到嘌呤结石，但其患病率随年龄降低（婴儿中为28.6%，大龄儿童中为18.5%）。