Nishimura H, Ida Y, Tanaka M
Department of Pharmacology, Kurume University School of Medicine, Japan.
Pharmacol Biochem Behav. 1990 May;36(1):183-6. doi: 10.1016/0091-3057(90)90146-9.
Ro 15-1788 (0.5, 1, 5, or 20 mg/kg), a pure benzodiazepine receptor antagonist, was studied for its effect on the duration of immobility and the number of straw-climbing attempts in a modified forced-swim test with straw-suspension of rats. A single dose of 20 mg/kg of Ro 15-1788 injected IP prolonged only the duration of immobility with no effect on straw-climbing behavior, whereas both doses of 1 and 5 mg/kg of this compound significantly enhanced the number of straw-climbing attempts in an inverted U-shaped manner. Ro 15-1788 at 1 mg/kg significantly reversed the inhibitory effect of 1 mg/kg of diazepam on the number of straw-climbing attempts. It is suggested that the enhancing effect of low doses of Ro 15-1788 on straw-climbing behavior can be regarded as an index of its anxiogenic effect, by acting via central benzodiazepine receptors.
Ro 15 - 1788（0.5、1、5或20毫克/千克）是一种纯苯二氮䓬受体拮抗剂，在一项改良的大鼠悬杆强迫游泳试验中，研究了其对不动时间和攀爬悬杆尝试次数的影响。腹腔注射20毫克/千克的Ro 15 - 1788单次剂量仅延长了不动时间，对攀爬悬杆行为无影响，而该化合物1毫克/千克和5毫克/千克的剂量均以倒U形方式显著增加了攀爬悬杆的尝试次数。1毫克/千克的Ro 15 - 1788显著逆转了1毫克/千克地西泮对攀爬悬杆尝试次数的抑制作用。提示低剂量Ro 15 - 1788对攀爬悬杆行为的增强作用可通过作用于中枢苯二氮䓬受体，被视为其致焦虑作用的一个指标。
