肿瘤诱导肿瘤浸润 CD8+淋巴细胞中 TCR 介导的信号转导的近端破坏，使抗肿瘤效应阶段失活。
Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.
机构信息
Department of Cell Biology, New York University Langone Medical Center, 550 First Avenue, New York, NY 10016, USA.
出版信息
J Immunol. 2010 Dec 15;185(12):7133-40. doi: 10.4049/jimmunol.1001157.
Abstract
The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8(+) T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated clearance is not attributable to immunological ignorance. However, tumor-infiltrating lymphocytes are defective in effector phase function, demonstrating tumor-induced immune suppression that likely underlies tumor escape. Since exocytosis of lytic granules is dependent upon TCR-mediated signal transduction, it is a reasonable contention that tumors may induce defective signal transduction in tumor infiltrating T cells. In this review, we consider the biochemical basis for antitumor T cell dysfunction, focusing on the role of inhibitory signaling receptors in restricting TCR-mediated signaling in tumor-infiltrating lymphocytes.
摘要
在癌症组织中存在 Ag 特异性、激活的肿瘤浸润 CD8(+) T 细胞证明肿瘤表达了能够引发免疫反应的 Ag。因此，一般来说，肿瘤逃避免疫介导的清除并非归因于免疫忽视。然而，肿瘤浸润淋巴细胞在效应期功能上存在缺陷，表明肿瘤诱导的免疫抑制可能是肿瘤逃逸的基础。由于溶酶体颗粒的胞吐作用依赖于 TCR 介导的信号转导，因此可以合理地认为肿瘤可能诱导肿瘤浸润 T 细胞中缺陷的信号转导。在这篇综述中，我们考虑了抗肿瘤 T 细胞功能障碍的生化基础，重点关注抑制性信号受体在限制肿瘤浸润淋巴细胞中 TCR 介导的信号转导中的作用。
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