B7-h3及其在抗肿瘤免疫中的作用。
B7-h3 and its role in antitumor immunity.
作者信息
Loos Martin, Hedderich Dennis M, Friess Helmut, Kleeff Jörg
机构信息
Chirurgische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Germany.
出版信息
Clin Dev Immunol. 2010;2010:683875. doi: 10.1155/2010/683875. Epub 2010 Nov 28.
Abstract
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.
摘要
B7-H3是共刺激分子B7/CD28超家族中最近发现的成员之一，作为T细胞反应的辅助调节因子。最近，有报道称B7-H3在几种人类癌症中表达，这表明B7-H3作为抗肿瘤免疫调节因子具有额外的功能。然而，其确切的生理作用仍然难以捉摸，因为已经证明它具有刺激和抑制能力。本文总结了关于B7-H3在调节T细胞反应方面的现有数据，重点关注其在抗肿瘤免疫中的潜在作用。
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本文引用的文献
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Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1343-9. doi: 10.1016/j.ijrobp.2010.01.061. Epub 2010 Jul 2.
2
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
J Clin Oncol. 2010 Jul 1;28(19):3167-75. doi: 10.1200/JCO.2009.26.7609. Epub 2010 Jun 1.
3
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas.
Mod Pathol. 2010 Aug;23(8):1104-12. doi: 10.1038/modpathol.2010.95. Epub 2010 May 21.
4
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Cancer Immunol Immunother. 2010 Aug;59(8):1163-71. doi: 10.1007/s00262-010-0841-1. Epub 2010 Mar 24.
5
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BMC Cancer. 2009 Dec 26;9:463. doi: 10.1186/1471-2407-9-463.
6
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Br J Cancer. 2009 Nov 17;101(10):1709-16. doi: 10.1038/sj.bjc.6605375. Epub 2009 Oct 20.
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Clin Cancer Res. 2009 Oct 15;15(20):6446-53. doi: 10.1158/1078-0432.CCR-09-1339. Epub 2009 Oct 6.
8
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