厚朴酚与阿霉素在聚乙二醇-聚乳酸纳米粒中的共递送

Co-delivery honokiol and doxorubicin in MPEG-PLA nanoparticles.

作者信息

Wang Bilan, Gou Maling, Zheng Xiuling, Wei Xiawei, Gong Changyang, Wang Xiuhong, Zhao Yinglan, Luo Feng, Chen Lijuan, Qian Zhiyong, Yang Li

机构信息

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.

出版信息

J Nanosci Nanotechnol. 2010 Jul;10(7):4166-72. doi: 10.1166/jnn.2010.2208.

DOI:10.1166/jnn.2010.2208

PMID:21128396

Abstract

The combination chemotherapy is an important protocol in cancer therapy. Honokiol shows synergistic anticancer effect with doxorubicin. In this paper, honokiol and doxorubicin co-loaded MPEG-PLA nanoparticles were prepared. The particle size, morphology, in vitro release profile, cytotoxicity and cell proliferation study were studied in detail. The results indicated that honokiol and doxorubicin could be efficiently loaded into MPEG-PLA nanoparticles simultaneously, and could be released out in an extended period in vitro. Meanwhile, honokiol and doxorubicin in MPEG-PLA nanoparticle could efficiently suppress cancer cell proliferation in vitro. The described honokiol and doxorubicin co-loaded MPEG-PLA nanoparticle might be a novel anticancer agent.

摘要

联合化疗是癌症治疗中的一项重要方案。厚朴酚与阿霉素显示出协同抗癌作用。本文制备了载有厚朴酚和阿霉素的聚乙二醇-聚乳酸（MPEG-PLA）纳米粒。详细研究了其粒径、形态、体外释放曲线、细胞毒性和细胞增殖情况。结果表明，厚朴酚和阿霉素可同时有效负载到MPEG-PLA纳米粒中，并能在体外长时间释放。同时，MPEG-PLA纳米粒中的厚朴酚和阿霉素可在体外有效抑制癌细胞增殖。所述载有厚朴酚和阿霉素的MPEG-PLA纳米粒可能是一种新型抗癌剂。