Department of Pharmacology & Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781022, Assam, India.
J Ethnopharmacol. 2011 Mar 8;134(1):62-6. doi: 10.1016/j.jep.2010.11.044. Epub 2010 Dec 2.
Leaves of Plantago erosa ex Roxb are used traditionally in Northeast India in different illnesses which include wounds, cuts, bruises, insect bites, poison-ivy rashes, minor sores and snakebite, etc.
Plantago erosa is one of the commonly used medicinal plants in various inflammatory conditions in this region; however, due to paucity of scientific literature on its anti-inflammatory property, the present study was aimed at evaluating its anti-inflammatory activity in the leaves using in vivo models of inflammation.
Different models like carageenan induced paw edema in rat and mice, formalin induced paw licking in rats and cotton pellet induced granuloma in rats were used for studying the anti-inflammatory activity in methanol extract of Plantago erosa (PEME) leaves.
The PEME at the oral doses from 300 to 600 mg/kg showed anti-inflammatory activity in various models. The extract (PEME) reduced carageenan induced paw edema in rat and mice, inhibited the formation of granulomatous tissue in cotton pellet induced granuloma after treatment and also decreased the reaction time in both early and late phases in formalin induced paw licking in rats.
The study evidently confirmed anti-inflammatory activity of PEME and thus supported the traditional claim. The anti-inflammatory activity could be attributed to the phytoconstituent (flavonoids, alkaloids and steroid) present in the methanol extract of the plant.
车前草的叶子在印度东北部传统上用于治疗各种疾病，包括伤口、割伤、瘀伤、昆虫叮咬、毒葛皮疹、小溃疡和蛇咬伤等。
车前草是该地区各种炎症情况下常用的药用植物之一；然而，由于关于其抗炎特性的科学文献很少，因此本研究旨在使用体内炎症模型评估其叶子的抗炎活性。
使用不同的模型，如大鼠和小鼠的角叉菜胶诱导的足肿胀、大鼠的甲醛诱导的足舔舐和大鼠的棉塞诱导的肉芽肿，研究车前草（PEME）叶子甲醇提取物的抗炎活性。
PEME 在 300 至 600mg/kg 的口服剂量下在各种模型中表现出抗炎活性。该提取物（PEME）可减少大鼠和小鼠的角叉菜胶诱导的足肿胀，抑制棉塞诱导的肉芽肿中肉芽组织的形成，并减少甲醛诱导的大鼠足舔舐中早期和晚期的反应时间。
该研究显然证实了 PEME 的抗炎活性，从而支持了传统说法。抗炎活性可能归因于植物甲醇提取物中的植物成分（类黄酮、生物碱和类固醇）。
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