Department of Biology and Biotechnology, Faculty of Science, Hashemite University, Zarka, Jordan.
Pharm Biol. 2010 Oct;48(10):1149-56. doi: 10.3109/13880200903530763.
The leaf of sage Salvia officinalis L. (Lamiaceae) is reputed in the folk medicine of Arabia, and Jordan in particular, to relieve pain associated with gastrointestinal disturbance.
Evaluation of the antinociceptive and anti-inflammatory activities of aqueous and butanol extracts of S. officinalis leaf.
The analgesic effects of the aqueous extract (10, 31.6, 100, 316, 1000 mg/kg) and butanol extract (10, 31.6, 100, 316 mg/kg) were studied using the hot-plate test for mice and the formalin-induced paw licking in rats. The effects were compared to those of morphine and the influence of naloxone on these effects was also evaluated. The same concentrations of both extracts were used to evaluate their anti-inflammatory effects using the cotton pellet granuloma and carrageenan-induced paw edema in rats.
The aqueous extract (10, 31.6, 100, 316, 1000 mg/kg) and butanol extract (10, 31.6, 100, 316 mg/kg) caused analgesic effect in the hot-plate latency assay as well as in early and late phases of formalin-induced paw licking in rats. These effects were reduced by the opioid receptor antagonist, naloxone (5 mg/kg). The same range of doses of both extracts caused dose-dependent inhibition of carrageenan-induced paw edema in rats as well as inhibition of cotton pellet granuloma.
These observations suggest that the sage leaf aqueous and butanol extracts have analgesic and anti-inflammatory effects, confirming the traditional use of this plant for pain alleviation.
唇形科鼠尾草（Salvia officinalis L.）的叶子在阿拉伯民间医学中，特别是在约旦，被认为可以缓解与胃肠道不适相关的疼痛。
评价鼠尾草叶的水提物和丁醇提物的镇痛和抗炎活性。
采用热板法和甲醛诱导的大鼠舔足法，研究水提物（10、31.6、100、316、1000 mg/kg）和丁醇提物（10、31.6、100、316 mg/kg）的镇痛作用。将这些作用与吗啡的作用进行比较，并评估纳洛酮对这些作用的影响。使用相同浓度的两种提取物，通过棉垫肉芽肿和角叉菜胶诱导的大鼠足肿胀来评估其抗炎作用。
水提物（10、31.6、100、316、1000 mg/kg）和丁醇提物（10、31.6、100、316 mg/kg）在热板潜伏期试验以及甲醛诱导的大鼠舔足早期和晚期均产生镇痛作用。这种作用被阿片受体拮抗剂纳洛酮（5 mg/kg）所减弱。两种提取物的相同剂量范围均能剂量依赖性地抑制角叉菜胶诱导的大鼠足肿胀，并抑制棉垫肉芽肿。
这些观察结果表明，鼠尾草叶的水提物和丁醇提物具有镇痛和抗炎作用，证实了这种植物在缓解疼痛方面的传统用途。
