报告的宫内接触烟草烟雾的可重复性。
Reproducibility of reported in utero exposure to tobacco smoke.
机构信息
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Human and Health Services, Durham, NC 27709, USA.
出版信息
Ann Epidemiol. 2011 Jan;21(1):48-52. doi: 10.1016/j.annepidem.2010.10.008.
PURPOSE
In studies of the fetal origins of disease and life course epidemiology, measures of fetal exposure may be based on information reported by the adults who were exposed in utero. In particular, the full spectrum of consequences of in utero exposure to maternal tobacco smoking is now an area of active investigation, and the ability to report such exposure reproducibly is of interest. We evaluated the reproducibility of in utero exposure to tobacco smoke, reported by the adult daughter during consecutive pregnancies.
METHODS
This study was based on 11,257 women who enrolled for more than one pregnancy in the Norwegian Mother and Child Cohort Study (MoBa). Participants completed a questionnaire around 17 weeks of gestation, which asked about their in utero exposure to tobacco smoke. Kappa statistics were calculated. Determinants of agreement were evaluated using logistic regression.
RESULTS
Weighted Kappa for in utero exposure for the first and second reports was 0.80. Determinants of agreement were higher education (better) and longer time between reports (worse).
CONCLUSIONS
Information on in utero exposure to maternal tobacco smoking provided by adult women was highly reproducible in this population.
目的
在疾病胎儿起源和生命过程流行病学研究中，胎儿暴露的测量可能基于宫内暴露的成年人所报告的信息。特别是，目前正在积极研究宫内接触母体吸烟的全部后果，因此能够重复报告这种暴露情况引起了人们的兴趣。我们评估了成年女儿在连续妊娠期间报告的宫内烟草烟雾暴露的可重复性。
方法
本研究基于挪威母亲和儿童队列研究（MoBa）中超过一次妊娠的 11257 名女性。参与者在妊娠约 17 周时完成了一份关于其宫内接触烟草烟雾的调查问卷。计算 Kappa 统计量。使用逻辑回归评估一致性的决定因素。
结果
第一和第二份报告中宫内暴露的加权 Kappa 值为 0.80。一致性的决定因素是受教育程度较高（更好）和报告之间的时间间隔较长（更差）。
结论
在该人群中，成年女性提供的关于母亲吸烟的宫内暴露信息具有高度可重复性。
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